FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE FLOATING MICROBALLOONS OF POORLY WATER-SOLUBLE DRUG DIACEREIN

Formulation and Evaluation of Gastroretentive Floating Microballoons of Norfloxacin

Formulation and Evaluation of Gastroretentive Floating Microballoons of Anti diabetic drug

The objective of present investigation is to design a sustained release floating microballoons of Metformin HCl using two polymers of different permeability characteristics Cellulose Acetate Butyrate (MW of 16,000) and Eudragit RS 100 (MW of 150,000) using the oil-in-oil emulsion solvent evaporation method. The prepared microballoons were studied for drug release behavior in simulated gastric f...

Formulation and in vitro characterization of cefpodoxime proxetil gastroretentive microballoons

BACKGROUND AND THE PURPOSE OF THE STUDY The objective of the present work was to improve bioavailability of cepodoxime proxetil through gastroretentive microballoon formulation. METHODS Microballoons of cefpodoxime proxetil were formulated by solvent evaporation and diffusion method employing hydroxypropylmethyl cellulose (HPMC) and ethyl cellulose (EC) polymers and characterized for particle...

Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability.

The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formulation strategies to increase the dissolution rate of carbamazepine. Influence of increased disso...

Formulation of Gastroretentive floating microparticles for Ofloxacin

In the present study an attempt was made to prepare alginate floating microparticles by ionotropic gelation method with calcium carbonate (CaCO3) 1% w/v in gelation medium used as gas-forming agent for oral delivery of Ofloxacin. Chitosan was used to enhance the drug encapsulation efficiency. Various physiochemical properties such as particle size, shape, in vitro buoyancy and drug release was ...